Scientists solve the mystery of a brain “switch” that can trigger weight loss in opposite ways

A mouse study found that activating GIPR in the brainstem and blocking it in the hypothalamus can both promote weight loss through different mechanisms. The discovery could support more effective combinations of obesity medicines.

一项小鼠研究发现，在脑干中激活GIPR和在下丘脑中阻断GIPR，都能通过不同机制促进减重。这一发现可能有助于开发更有效的肥胖症联合用药方案。